Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.

ABSTRACT:

Rationale & objective

Fibrosis is a major driver of chronic kidney disease, and epithelial-mesenchymal transition (EMT) may contribute to its development. A polyubiquitinated form of phosphatase and tensin homolog (PTEN^K27polyUb) promotes EMT in vitro. Thus, it is a potentially useful biomarker of progressive kidney fibrosis and may predict loss of kidney function.

Study design

Observational cohort study.

Setting & participants

Southwest United States, American Indians (154 women, 80 men) with or at high risk for diabetic kidney disease (DKD).

Predictors

Serum level of PTEN^K27polyUb.

Outcome

≥40% loss of glomerular filtration rate (GFR) or onset of kidney failure. Kidney structural measures in a subset of study participants who unde

SUBMITTER: Looker HC 

PROVIDER: S-EPMC9740738 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature