Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study.

ABSTRACT: The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to frui

SUBMITTER: Wang J 

PROVIDER: S-EPMC9740837 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature