Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.

ABSTRACT:

Background

Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.

Methods

The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.

Results

Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly b

SUBMITTER: Orru S 

PROVIDER: S-EPMC9740844 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature