Ontology highlight
ABSTRACT:
SUBMITTER: Yu N
PROVIDER: S-EPMC9740992 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20221125 23
In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv <i>t</i>-BuONa or PhONa, 30 °C), using aryl isocyanides and <i>O</i>-benzoyl hydroxylamines as the readily accessible starting materials. The reactions might undergo a cascade process involving isocyanide insertion into the N-O bond and Mumm-type rearrangement. This work represents a rare example of isocyanide insertion into N-O bonds, whic ...[more]