Identification of Altered Primary Immunodeficiency-Associated Genes and Their Implications in Pediatric Cancers.

ABSTRACT:

Background

Cancer is the leading cause of disease-related mortality in children and malignancies are more frequently observed in individuals with primary immunodeficiencies (PIDs). This study aimed to identify and highlight the molecular mechanisms, such as oncogenesis and immune evasion, by which PID-related genes may lead to the development of pediatric cancers.

Method

We implemented a novel bioinformatics framework using patient data from the TARGET database and performed a comparative transcriptome analysis of PID-related genes in pediatric cancers between normal and cancer tissues, gene ontology enrichment, and protein-protein interaction analyses, and determined the prognostic impacts of commonly mutated and differentially expressed PID-related genes.

Results

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SUBMITTER: Standing S 

PROVIDER: S-EPMC9741011 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature