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Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells.

ABSTRACT: Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti65-Zr18-Nb16-Mo1 (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the titanium alloys were measured, and the correlation with the cellular viability was investigated. Finally, the relative protein expression in cellular proliferation pathways was measured and compared with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR).

SUBMITTER: Ho WF

PROVIDER: S-EPMC9741175 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells.

Ho Wen-Fu WF Wong Ka-Kin KK Lee Mei-Hwa MH Thomas James L JL Chang Ya-Chun YC Wu Shih-Ching SC Hsu Hsueh-Chuan HC Lin Hung-Yin HY

International journal of molecular sciences 20221122 23

Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti65-Zr18-Nb16-Mo1 (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the ti ...[more]

PMID: 36498880

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Project description:The corrosion characteristics and passive behavior of as-cast Ni40Fe30Co20Al10 medium-entropy alloy (MEA) fabricated by the vacuum arc melting technique were investigated in 3.5 wt.% NaCl, 0.5 M HCl, and 0.5 M H2SO4 solutions. Although the impact of different solutions on the corrosion current density was not pronounced, the corrosion potential values of MEAs in H2SO4, HCl and NaCl solutions were -0.37, -0.58 and -1.16 V, respectively, indicating that the resistance to general corrosion in acidic solutions becomes strengthened. Through electrochemical passive region tests, surface morphology analysis and ICP testing, it was found that, due to the high-entropy effect and uniform single-phase structure, an optimized and stable passive film formed specifically in the Cl--containing solution. The ion concentrations in the passive region of MEA in NaCl solution were an order of magnitude lower than those of other two samples, suggesting that its passive film formed exhibits a more prominent capacity to inhibit metal dissolution. Compared with electrochemical reactions in H2SO4 and HCl solutions, MEA shows enhanced pitting resistance in NaCl solution, which could be attributed to the presence of abundant unoxidized metal atoms (51.9 at.%). Al is identified as the primary component in the formation of the passive film, which plays a protective role for the Co-rich interior of the MEA. Although MEA has a relatively high passivation current in the H2SO4 solution, it has the widest passivation zone (1.87 V), indicating the optimized stability of the formed passive film. Moreover, it displays a high level of resistance to pitting corrosion in the solution containing only H+- and free of Cl-. Both the MEAs show significant grain-boundary corrosion in H2SO4 and HCl solutions. Among them, the MEA in HCl experiences more severe intragranular corrosion. Notably, MEA withstands the erosion of a single Cl-- or H+-containing solution, but it is unable to resist the synergistic effect of a solution containing both H+ and Cl-.

Dataset Information

Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells.

Publications

Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells.

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