Drug Repurposing Applications to Overcome Male Predominance via Targeting G2/M Checkpoint in Human Esophageal Squamous Cell Carcinoma

ABSTRACT:

Simple Summary

Sex biases in cancer incidence and cancer mortality exist in the majority of cancer types. Esophageal squamous cell carcinoma (ESCC) is a typical malignancy with higher mortality rates and worse responses to treatment in males versus females. To overcome the male predominance in ESCC, more therapeutic targets need to be identified. Meanwhile, age is also an important contributor that should be included when we consider sex bias in cancer. In this study, we used multi-omics data from 663 ESCC patients and found that G2/M checkpoint pathway-related sex bias and age bias were significantly present in genomics, transcriptomics, and epigenomics. Our findings suggest that G2/M targets may be included in combination therapy for male patients to improve the efficacy of ESCC

SUBMITTER:  

PROVIDER: S-EPMC9741366 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature