Extensive proteome and functional genomic profiling of variability between genetically identical human B-lymphoblastoid cells.

ABSTRACT: In life-science research isogenic B-lymphoblastoid cell lines (LCLs) are widely known and preferred for their genetic stability - they are often used for studying mutations for example, where genetic stability is crucial. We have shown previously that phenotypic variability can be observed in isogenic B-lymphoblastoid cell lines. Isogenic LCLs present well-defined phenotypic differences on various levels, for example on the gene expression level or the chromatin level. Based on our investigations, the phenotypic variability of the isogenic LCLs is accompanied by certain genetic variation too. We have developed a compendium of LCL datasets that present the phenotypic and genetic variability of five isogenic LCLs from a multiomic perspective. In this paper, we present additional datasets gen

SUBMITTER: Laczik M 

PROVIDER: S-EPMC9741606 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature