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ABSTRACT:
SUBMITTER: Wakabayashi Y
PROVIDER: S-EPMC9741642 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Wakabayashi Yuka Y Miyatsuka Takeshi T Miura Masaki M Himuro Miwa M Taguchi Tomomi T Iida Hitoshi H Nishida Yuya Y Fujitani Yoshio Y Watada Hirotaka H
Scientific reports 20221210 1
As diabetes results from the absolute or relative deficiency of insulin secretion from pancreatic β cells, possible methods to efficiently generate surrogate β cells have attracted a lot of efforts. To date, insulin-producing cells have been generated from various differentiated cell types in the pancreas, such as acinar cells and α cells, by inducing defined transcription factors, such as PDX1 and MAFA, yet it is still challenging as to how surrogate β cells can be efficiently generated for est ...[more]