Tubulin Isotypes and Posttranslational Modifications in Vascular Dementia and Alzheimer's Disease.

ABSTRACT:

Background

Vascular dementia (VaD) and Alzheimer's disease (AD) are the two most common forms of dementia. Although these two types of dementia have different etiologies, they share some similarities in their pathophysiology, such as neuronal loss and decreased levels of tau protein. We hypothesize that these can have an impact upon the molecular changes in tubulin, precede the neuronal cell loss, and lead to changes in cytoskeletal associated proteins, as documented in both VaD and AD.

Objective

We characterized different isotypes of tubulin together with their posttranslational modifications, as well as several microtubule associated proteins (MAPs), such as tau protein, MAP2 and MAP6, all together known as the tubulin code.

Methods

We performed western blotting in

SUBMITTER: Santiago-Mujika E 

PROVIDER: S-EPMC9741746 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature