Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients.

ABSTRACT:

Background

We sought to determine whether differences in subtype distribution and differentially expressed genes exist between African Americans (AAs) and European Americans (EAs) in patients with high-risk nonmuscle-invasive bladder cancer (NMIBC).

Methods

We performed a retrospective cohort study including 26 patients (14 AAs and 12 EAs) from the University of Texas Medical Branch and the Durham Veterans Affair Health Care System from 2010 to 2020 among treatment naïve, high-risk NMIBC. Profiled gene expressions were performed using the UROMOL classification system.

Results

UROMOL racial subtype distributions were similar with class 2a being most common with 10 genes commonly upregulated in AAs compared to EAs including EFEMP1, S100A16, and MCL1 which are associated

SUBMITTER: You S 

PROVIDER: S-EPMC9741768 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature