A novel autophagy-related long non-coding RNAs prognostic risk score for clear cell renal cell carcinoma.

ABSTRACT:

Background

As the main histological subtype of renal cell carcinoma, clear cell renal cell carcinoma (ccRCC) places a heavy burden on health worldwide. Autophagy-related long non-coding RNAs (ARlncRs) have shown tremendous potential as prognostic signatures in several studies, but the relationship between them and ccRCC still has to be demonstrated.

Methods

The RNA-sequencing and clinical characteristics of 483 ccRCC patients were downloaded download from the Cancer Genome Atlas and International Cancer Genome Consortium. ARlncRs were determined by Pearson correlation analysis. Univariate and multivariate Cox regression analyses were applied to establish a risk score model. A nomogram was constructed considering independent prognostic factors. The Harrell concordance index c

SUBMITTER: Tang F 

PROVIDER: S-EPMC9741795 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature