Loss of Igf2 Gene Imprinting in Murine Prostate Promotes Widespread Neoplastic Growth.

ABSTRACT: Loss of imprinting (LOI) is an epigenetic event that relaxes an allele-specific restriction on gene expression. One gene that experiences LOI is the paracrine insulin-like growth factor IGF2, which occurs commonly in human prostate tissues during aging and tumorigenesis. However, the relationship between IGF2 LOI and prostate tumorigenesis has not been established functionally. In this study, we created a mouse model with CTCF-binding site mutations at the Igf2-H19 imprint control region that abolishes CTCF insulator activity, resulting in biallelic Igf2 expression that mimics increased levels seen with aging-induced LOI. We found that Igf2 LOI increased the prevalence and severity of prostatic intraepithelial neoplasia (PIN), a premalignant lesion. Engin

SUBMITTER: Damaschke NA 

PROVIDER: S-EPMC9741865 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature