Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function.

ABSTRACT:

Background

Many persons with a history of smoking tobacco have clinically significant respiratory symptoms despite an absence of airflow obstruction as assessed by spirometry. They are often treated with medications for chronic obstructive pulmonary disease (COPD), but supporting evidence for this treatment is lacking.

Methods

We randomly assigned persons who had a tobacco-smoking history of at least 10 pack-years, respiratory symptoms as defined by a COPD Assessment Test score of at least 10 (scores range from 0 to 40, with higher scores indicating worse symptoms), and preserved lung function on spirometry (ratio of forced expiratory volume in 1 second [FEV₁] to forced vital capacity [FVC] ≥0.70 and FVC ≥70% of the predicted value after bronchodilator use) to rec

SUBMITTER: Han MK 

PROVIDER: S-EPMC9741866 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature