Bone marrow mesenchymal stem cell-derived exosomal LINC00847 inhibits the proliferation, migration, and invasion of Ewing sarcoma.

ABSTRACT:

Background

Ewing sarcoma (ES) is one of the most lethal primary bone tumors with a poor survival rate. Current evidence suggests that extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) loaded with abundant biological functional lncRNAs confer therapeutic benefits against the development of various tumors.

Aim

This study aimed to investigate the role of exosomal lncRNAs from BMSCs in the pathogenesis of ES.

Methods

Bioinformatic analysis and quantitative real time-polymerase chain reaction (qRT-PCR) experiments were used to detect the expression level of LINC00847 in ES tissues and cells. Cell biology experiments examined the effect of in vitro proliferation, migration, and invasion abilities and the biological function of BMSCs-derive

SUBMITTER: Huang L 

PROVIDER: S-EPMC9741936 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature