Buprenorphine & methadone dosing strategies to reduce risk of relapse in the treatment of opioid use disorder.

ABSTRACT:

Background

Although there is consensus that having a "high-enough" dose of buprenorphine (BUP-NX) or methadone is important for reducing relapse to opioid use, there is debate about what this dose is and how it should be attained. We estimated the extent to which different dosing strategies would affect risk of relapse over 12 weeks of treatment, separately for BUP-NX and methadone.

Methods

This was a secondary analysis of three comparative effectiveness trials. We examined four dosing strategies: 1) increasing dose in response to participant-specific opioid use, 2) increasing dose weekly until some minimum dose (16 mg BUP, 100 mg methadone) was reached, 3) increasing dose weekly until some minimum and increasing dose in response to opioid use thereafter (referred to as the

SUBMITTER: Rudolph KE 

PROVIDER: S-EPMC9741946 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature