White matter microstructure and longitudinal relaxation time anisotropy in human brain at 3 and 7 T.

ABSTRACT: A high degree of structural order by white matter (WM) fibre tracts creates a physicochemical environment where water relaxations are rendered anisotropic. Recently, angularly dependent longitudinal relaxation has been reported in human WM. We have characterised interrelationships between T1 relaxation and diffusion MRI microstructural indices at 3 and 7 T. Eleven volunteers consented to participate in the study. Multishell diffusion MR images were acquired with b-values of 0/1500/3000 and 0/1000/2000 s/mm² at 1.5 and 1.05 mm³ isotropic resolutions at 3 and 7 T, respectively. DTIFIT was used to compute DTI indices; the fibre-to-field angle (θ_FB ) maps were obtained using the principal eigenvector images. The orientations and volume fractions of multiple fib

SUBMITTER: Kauppinen RA 

PROVIDER: S-EPMC9742158 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature