Comparison of two types of microscopic diffusion anisotropy in mouse brain.

ABSTRACT: Two distinct types of microscopic diffusion anisotropy (MA) are compared in brain for both normal control and transgenic (3xTg-AD) mice, which develop Alzheimer's disease pathology. The first type of MA is the commonly used microscopic fractional anisotropy (μFA), and the second is a new MA measure referred to as μFA'. These two MA parameters have different symmetry properties that are central to their physical interpretations. Specifically, μFA is invariant with respect to local rotations of compartmental diffusion tensors while μFA' is invariant with respect to global diffusion tensor deformations. A key distinction between μFA and μFA' is that μFA is affected by the same type of orientationally coherent diffusion anisotropy as the conventional fractional anisotropy (FA) while μFA' is no

SUBMITTER: Jensen JH 

PROVIDER: S-EPMC9742172 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature