Donor selection for adoptive cell therapy with CD45RA^- memory T cells for patients with coronavirus disease 2019, and dexamethasone and interleukin-15 effects on the phenotype, proliferation and interferon gamma release.

ABSTRACT:

Background aims

We have previously demonstrated the safety and feasibility of adoptive cell therapy with CD45RA^- memory T cells containing severe acute respiratory syndrome coronavirus 2-specific T cells for patients with coronavirus disease 2019 from an unvaccinated donor who was chosen based on human leukocyte antigen compatibility and cellular response. In this study, we examined the durability of cellular and humoral immunity within CD45RA^- memory T cells and the effect of dexamethasone, the current standard of care treatment, and interleukin-15, a cytokine critically involved in T-cell maintenance and survival.

Methods

We performed a longitudinal analysis from previously severe acute respiratory syndrome coronavirus 2-infected and infection-naïve i

SUBMITTER: Al-Akioui-Sanz K 

PROVIDER: S-EPMC9742221 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature