Lacosamide decreases neonatal seizures without increasing apoptosis.

ABSTRACT:

Objective

Many seizing neonates fail to respond to first-line anticonvulsant medications. Phenobarbital, an allosteric modulator of γ-aminobutyric acid type A (GABA_A ) receptors, has low efficacy in treating neonatal seizures and causes neuronal apoptosis. Nonetheless, it is one of the most used anticonvulsants in this age group. In neonatal mice, phenobarbital's poor effectiveness is due in part to high intraneuronal chloride concentration, which causes GABA to exert depolarizing actions. Therefore, another approach to treat neonatal seizures could be to use anticonvulsants that do not rely on GABAergic modulation. We evaluated whether lacosamide decreases seizures in neonatal mice and whether it increases apoptosis in vitro and in vivo.

Methods

In vitro, we meas

SUBMITTER: Langton RL 

PROVIDER: S-EPMC9742288 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature