Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.

ABSTRACT: Elucidating the neural circuits supporting odor identification remains an open challenge. Here, we analyze the contribution of the two output cell types of the mouse olfactory bulb (mitral and tufted cells) to decode odor identity and concentration and its dependence on top-down feedback from their respective major cortical targets: piriform cortex versus anterior olfactory nucleus. We find that tufted cells substantially outperform mitral cells in decoding both odor identity and intensity. Cortical feedback selectively regulates the activity of its dominant bulb projection cell type and implements different computations. Piriform feedback specifically restructures mitral responses, whereas feedback from the anterior olfactory nucleus preferentially controls the gain of tufted representati

SUBMITTER: Chae H 

PROVIDER: S-EPMC9742324 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature