Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.

ABSTRACT:

Aims/hypothesis

People with isolated impaired fasting glucose (IFG) have normal beta cell function. We hypothesised that an increased glucose threshold for beta cell secretion explains IFG.

Methods

We used graded glucose infusion to examine the relationship of insulin secretion rate (ISR) and glucagon secretion rate (GSR) with rising glucose. We studied 39 non-diabetic individuals (53 ± 2 years, BMI 30 ± 1 kg/m²), categorised by fasting glucose and glucose tolerance status. After an overnight fast, a variable insulin infusion was used to maintain glucose at ~4.44 mmol/l (07:00 to 08:30 hours). At 09:00 hours, graded glucose infusion commenced at 1 mg kg^-1 min^-1 and doubled every 60 min until 13:00 hours. GSR and ISR were calculated by nonpara

SUBMITTER: Kohlenberg JD 

PROVIDER: S-EPMC9742343 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature