APOE ε4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease.

ABSTRACT:

Introduction

Apolipoprotein E (APOE) ε4 is an important genetic risk factor for typical Alzheimer's disease (AD), influencing brain volume and tau burden. Little is known about its influence in atypical presentations of AD.

Methods

An atypical AD cohort of 140 patients diagnosed with either posterior cortical atrophy or logopenic progressive aphasia underwent magnetic resonance imaging and positron emission tomography. Linear mixed effects models were fit to assess the influence of APOE ε4 on cross-sectional and longitudinal regional metrics.

Results

At baseline, APOE ε4 carriers had smaller hippocampal and amygdala volumes and greater tau standardized uptake volume ratio in the hippocampus and entorhinal cortex compared to non-carriers while longitudinally, APOE ε4 n

SUBMITTER: Singh NA 

PROVIDER: S-EPMC9742387 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature