Characteristics of gut microbiota and fecal metabolomes in patients with celiac disease in Northwest China.

ABSTRACT: Celiac disease (CD) is an autoimmune small bowel disease. The pattern of gut microbiota is closely related to dietary habits, genetic background, and geographical factors. There is a lack of research on CD-related gut microbiota in China. This study aimed to use 16S rDNA sequencing and metabolomics to analyze the fecal microbial composition and metabolome characteristics in patients diagnosed with CD in Northwest China, and to screen potential biomarkers that could be used for its diagnosis. A significant difference in the gut microbiota composition was observed between the CD and healthy controls groups. At the genus level, the abundance of Streptococcus, Lactobacillus, Veillonella, and Allisonella communities in the CD group were increased (Q < 0.05). F

SUBMITTER: Shi T 

PROVIDER: S-EPMC9742481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature