Novel pyroptosis-associated genes signature for predicting the prognosis of sarcoma and validation.

ABSTRACT:

Background

Sarcoma is a rare mesenchymal malignant tumor. Recently, pyroptosis has been reported to be a mode of programmed cell death. Nonetheless, levels of pyroptosis-associated genes in sarcoma and its relevance to prognostic outcomes are yet to be elucidated.

Results

Sarcoma cases were classified into two subtypes with regards to differentially expressed genes. We established a profile composed of seven genes and classified the sarcoma patients into low- and high-risk groups through least absolute shrinkage and selection operator Cox regression. Survival rate of low-risk sarcoma patients was markedly higher, relative to high-risk group (P<0.001). In combination with clinical features, the risk score was established to be an independent predictive factor for OS of sarcom

SUBMITTER: Wen H 

PROVIDER: S-EPMC9742515 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature