Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer.

ABSTRACT:

Introduction

Breast cancer (BC) has been ranking first in incidence and the leading cause of death among female cancers worldwide based on the latest report. Regulated cell death (RCD) plays a significant role in tumor initiation and provides an important target of cancer treatment. Cuproptosis, a novel form of RCD, is ignited by mitochondrial stress, particularly the lipoylated mitochondrial enzymes aggregation. However, the role of cuproptosis-related genes (CRGs) in tumor generation and progression remains unclear.

Methods

In this study, the mRNA expression data of CRGs in BC and normal breast tissue were extracted from TCGA database, and protein expression patterns of these CRGs were analyzed using UALCAN. The prognostic values of CRGs in BC were explored by using Kaplan

SUBMITTER: Huang T 

PROVIDER: S-EPMC9742524 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature