Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus.

ABSTRACT:

Introduction

The prevalence of Gestational Diabetes Mellitus (GDM) is increasing globally, and high levels of triglyceride (TG) and low levels of free thyroxine (FT4) in early pregnancy are associated with an increased risk of GDM; however, the interaction and mediation effects remain unknown. The aim of the present study is to examine the impact of FT4 and TG combined effects on the prevalence of GDM and the corresponding casual paths among women in early pregnancy.

Materials and methods

This study comprised 40,156 pregnant women for whom early pregnancy thyroid hormones, fasting blood glucose as well as triglyceride were available. GDM was diagnosed using a 2-hour 75-g oral glucose tolerance test (OGTT) according to the American Diabetes Association guidelines, and the pre

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9742591 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature