Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors.

ABSTRACT:

Background

SARS-CoV2 can induce a strong host immune response. Many studies have evaluated antibody response following SARS-CoV2 infections. This study investigated the immune response and T cell receptor diversity in people who had recovered from SARS-CoV2 infection (COVID-19).

Methods

Using the nCounter platform, we compared transcriptomic profiles of 162 COVID-19 convalescent donors (CCD) and 40 healthy donors (HD). 69 of the 162 CCDs had two or more time points sampled.

Results

After eliminating the effects of demographic factors, we found extensive differential gene expression up to 241 days into the convalescent period. The differentially expressed genes were involved in several pathways, including virus-host interaction, interleukin and JAK-STAT signaling, T-ce

SUBMITTER: Gedda MR 

PROVIDER: S-EPMC9742656 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature