Establishment of Rapid and Accurate Screening System for Molecular Target Therapy of Osteosarcoma.

ABSTRACT: Introduction Comprehensive analyses using clinical sequences subcategorized osteosarcoma (OS) into several groups according to the activated signaling pathways. Mutually exclusive co-occurrences of gene amplification (PDGFRA/KIT/KDR, VEGFA/CCND3, and MDM2/CDK4) have been identified in approximately 40% of OS, representing candidate subsets for clinical evaluation of additional therapeutic options. Thus, it would be desirable to evaluate the specific gene amplification before starting therapy in patients with OS. Materials and Methods This is a retrospective study. We examined 13 cases of clinical OS samples using NanoString-based copy number variation (CNV) analysis. Decalcification and chemotherapeutic effects on this analysis were also assessed. Results

SUBMITTER: Sasa K 

PROVIDER: S-EPMC9742709 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature