Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?

ABSTRACT: Major hallmarks of functional loss, loss of metabolic and musculoskeletal health and (multi)morbidity with aging are associated with sleep disturbances. With poor sleep shifts in gut microbial composition commonly manifest, which could mediate the pro-inflammatory state between sleep disturbances and sarcopenia. This systematic review presents the recent evidence on how sleep disturbances throughout the lifespan associate with and contribute to gut microbial composition changes, proposing a mechanism to understand the etiology of sarcopenia through sleep disturbances. The relationship between disturbed sleep and clinically relevant gut microbiota composition on health aspects of aging is discussed. A search was performed in PubMed, Cochrane Library, Scopus, Web of Science using keywords in

SUBMITTER: Morwani-Mangnani J 

PROVIDER: S-EPMC9742900 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature