A proteomic study to unveil lead toxicity-induced memory impairments invoked by synaptic dysregulation.

ABSTRACT: Lead (Pb²⁺), a ubiquitously present heavy metal toxin, has various detrimental effects on memory and cognition. However, the molecular processes affected by Pb²⁺ causing structural and functional anomalies are still unclear. To explore this, we employed behavioral and proteomic approaches using rat pups exposed to lead acetate through maternal lactation from postnatal day 0 (P0) until weaning. Behavioral results from three-month-old rats clearly emphasized the early life Pb²⁺ exposure induced impairments in spatial cognition. Further, proteomic analysis of synaptosomal fractions revealed differential alteration of 289 proteins, which shows functional significance in elucidating Pb²⁺ induced physiological changes. Focusing on the association of Sm

SUBMITTER: Mohanraj N 

PROVIDER: S-EPMC9742914 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature