Kolaviron alleviates haematological abnormalities and hepato-renal damage in Naja nigricollis nigricollis venom-treated rats.

ABSTRACT:

Objectives

To investigate the effect of kolaviron against haematological abnormalities and hepato-renal damage in Naja n. nigricollis (NNN) venom-treated rats.

Methods

Twenty-four male rats were grouped into four (n = 6). A single intravenous dose of NNN venom (≈½LD₅₀) was given to group B-D (excluding A). All the groups were immediately treated intraperitoneally as follows: A (Normal control) and B (Envenom) received 0.40 mL/kg of 0.1% Tween 80, while C and D (test groups), received 200 and 400 mg/kg of kolaviron respectively. After 6 h, they were anaesthetized, and sacrificed.

Results

NNN-venom LD₅₀ was estimated at 1.14 mg/kg. Injected half LD₅₀, after 6 h, caused significant (p < 0.05) decreases in RBC, HGB and PCV, with inc

SUBMITTER: Okafor AI 

PROVIDER: S-EPMC9742948 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature