Stimulation of distinct parietal locations differentiates frontal versus hippocampal network involvement in memory formation.

ABSTRACT: Adjacent regions of parietal cortex are thought to affiliate with distinct large-scale networks and thereby make different contributions to memory formation. We directly tested this putative functional segregation within parietal cortex by perturbing activity of anterior versus posterior parietal areas. We applied noninvasive theta-burst transcranial magnetic stimulation to these locations immediately before a semantic encoding task, and subsequently tested recollection memory. Consistent with previous findings, fMRI activity in left inferior frontal gyrus during semantic encoding correlated with subsequent high memory accuracy and strong subjective recollection. Stimulation of the posterior parietal cortex decoupled its network - the hippocampal-cortical network - from left inferior front

SUBMITTER: Dave S 

PROVIDER: S-EPMC9743066 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature