Ontology highlight
ABSTRACT:
SUBMITTER: Luckmann M
PROVIDER: S-EPMC9743428 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Lückmann Michael M Shenol Aslihan A Nissen Tinne A D TAD Petersen Jacob E JE Kouvchinov David D Schwartz Thue W TW Frimurer Thomas M TM
ACS medicinal chemistry letters 20221102 12
The free fatty acid receptors FFAR1 and FFAR4 are considered promising therapeutic targets for management of metabolic and inflammatory diseases. However, there is a need for entirely novel chemical scaffolds, since many of the highly similar lipophilic chemotypes in development have been abandoned by the pharmaceutical industry, due to toxic effects on hepatocytes and β-cells. Our group has recently reported the discovery of a 1,3,5-triazine-2-amine-based compound that acts as an allosteric ago ...[more]