Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling.

ABSTRACT:

Background

Autoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies. The matricellular protein osteopontin (OPN) has been linked to SLE pathogenesis, as SLE patients show increased serum levels of OPN and often polymorphisms in its gene. Although widely studied for its pro-tumorigenic role in different solid tumours, the role of OPN in autoimmunity-driven lymphomagenesis has not been investigated yet.

Methods

To test the role of OPN in the SLE-associated lymphomagenesis, the SLE-like prone Fas^lpr/lpr mutation was transferred onto an OPN-deficient background. Spleen from Fas^lpr/lpr and OPN-/-Fas^lpr/lpr mice, as well as purified B cells, were analysed by histopatho

SUBMITTER: Rizzello C 

PROVIDER: S-EPMC9743519 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature