Transcriptomic landscape of TIMP3 oncosuppressor activity in thyroid carcinoma.

ABSTRACT:

Background

Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in several tumor types. TIMP3 is frequently downregulated in PTC by promoter methylation. We have previously functionally demonstrated that TIMP3 exerts an oncosuppressor role in PTC: TIMP3 restoration in the PTC-derived NIM1 cell line affects in vitro migration, invasion and adhesive capability, while reduces tumor growth, angiogenesis and macrophage recruitment in vivo. To get a deeper insight on the mediators of TIMP3 oncosuppressor activity in thyroid tumors, here we focused on the TIMP3 related transcriptome.

Methods

TCGA database was used for investigating

SUBMITTER: Mazzoni M 

PROVIDER: S-EPMC9743531 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature