LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer.

ABSTRACT:

Background and purpose

Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). However, a subset of HPV-positive OPSCC patients still experience poor outcomes. Furthermore, HPV-negative OPSCC patients, who have an even higher risk of relapse, are still lacking suitable prognostic biomarkers for clinical outcome. Here, we evaluated the prognostic value of LINE-1 methylation level in OPSCC patients and further addressed the relationship between LINE-1 methylation status and p53 protein expression as well as genome-wide/gene-specific DNA methylation.

Results

In this study, DNA was extracted from 163 formalin-fixed paraffin-embedde

SUBMITTER: Casarotto M 

PROVIDER: S-EPMC9743592 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature