Regulation of mitochondrial complex III activity and assembly by TRAP1 in cancer cells.

ABSTRACT:

Background

Metabolic reprogramming is an important issue in tumor biology. A recently-identified actor in this regard is the molecular chaperone TRAP1, that is considered an oncogene in several cancers for its high expression but an oncosuppressor in others with predominant oxidative metabolism. TRAP1 is mainly localized in mitochondria, where it interacts with respiratory complexes, although alternative localizations have been described, particularly on the endoplasmic reticulum, where it interacts with the translational machinery with relevant roles in protein synthesis regulation.

Results

Herein we show that, inside mitochondria, TRAP1 binds the complex III core component UQCRC2 and regulates complex III activity. This decreases respiration rate during basal conditions bu

SUBMITTER: Matassa DS 

PROVIDER: S-EPMC9743594 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature