Clustering of pediatric onset inflammatory bowel disease in Finland: a nationwide register-based study.

ABSTRACT:

Background

The incidence of pediatric inflammatory bowel disease (PIBD) has increased dramatically during the past decades. This implies involvement of environmental factors in etiology but lends no clues about specific agents. We evaluated clustering in time and place of residence at PIBD onset using a case-control setting with comprehensive nationwide register data.

Methods

We included all PIBD cases diagnosed at ages < 18 years during 1992-2017 (3748 cases; median age of 14.6; 2316 (58%) with ulcerative colitis (UC), 1432 with Crohn's, and 18,740 age- and sex-matched controls) and constructed complete residential histories (including coordinates) from the national database until the date of the diagnosis of the case assigned as index date for the controls. Using the coord

SUBMITTER: Nikkila A 

PROVIDER: S-EPMC9743626 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature