The role of Neanderthal introgression in liver cancer.

ABSTRACT:

Background

Neanderthal introgressed DNA has been linked to different normal and disease traits including immunity and metabolism-two important functions that are altered in liver cancer. However, there is limited understanding of the relationship between Neanderthal introgression and liver cancer risk. The aim of this study was to investigate the relationship between Neanderthal introgression and liver cancer risk.

Methods

Using germline and somatic DNA and tumor RNA from liver cancer patients from The Cancer Genome Atlas, along with ancestry-match germline DNA from unaffected individuals from the 1000 Genomes Resource, and allele specific expression data from normal liver tissue from The Genotype-Tissue Expression project we investigated whether Neanderthal introgression im

SUBMITTER: Taravella Oill AM 

PROVIDER: S-EPMC9743633 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature