Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station.

ABSTRACT:

Background

Monitoring the adaptation of microorganisms to the extreme environment of the International Space Station (ISS) is crucial to understanding microbial evolution and infection prevention. Acinetobacter pittii is an opportunistic nosocomial pathogen, primarily impacting immunocompromised patients, that was recently isolated from two missions aboard the ISS.

Results

Here, we report how ISS-associated A. pittii (n = 20 genomes) has formed its own genetically and functionally discrete clade distinct from most Earth-bound isolates (n = 291 genomes). The antimicrobial susceptibility testing of ISS strains and two related clinical isolates demonstrated that ISS strains acquired more resistance, specifically with regard to expanded-spectrum cephalosporins, despite no predic

SUBMITTER: Tierney BT 

PROVIDER: S-EPMC9743659 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature