Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria.

ABSTRACT:

Background

Malaria is a complex issue due to the availability of few therapies and chemical families against Plasmodium and mosquitoes. There is increasing resistance to various drugs and insecticides in Plasmodium and in the vector. Additionally, human behaviors are responsible for promoting resistance as well as increasing the risk of exposure to infections. Chalcones and their derivatives have been widely explored for their antimalarial effects. In this context, new derivatives of chalcones have been evaluated for their antimalarial efficacy.

Methods

BALB/c mice were infected with P. berghei NK-65. The efficacy of the three most potent chalcone derivations (1, 2, and 3) identified after an in vitro compound screening test was tested. The selected doses of 10 mg/kg, 20 mg/

SUBMITTER: Sinha S 

PROVIDER: S-EPMC9743746 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature