Rational Design of a Hybrid Peptide against Severe Acute Respiratory Syndrome Coronavirus 2 Using Melittin and Angiotensin-Converting Enzyme 2 as Pharmaceutical Agents.

ABSTRACT:

Background

Management of severe acute respiratory syndrome coronavirus 2 in humans depends on the availability of vaccines or effective drugs. Studies have shown that angiotensin-converting enzyme 2 (ACE2) is responsible for binding the viral spike glycoproteins to human cells. Melittin from the bee venom of Apis melifera is a peptide with antimicrobial activities.

Materials and methods

In this study, important amino acid residues of ACE2 interacting with spike glycoproteins of the virus were described based on the ACE2-spike-glycoprotein interface. This has been previously analyzed by Robson in crystal structures of the receptors and ligands. Flexible linkers and 31 amino acid residues from N-terminal of ACE2 as coronavirus spike binding domains (SBDs) were added to

SUBMITTER: Farhoudi R 

PROVIDER: S-EPMC9744085 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature