Psoriasis and Cardiovascular Disease: Novel Mechanisms and Evolving Therapeutics.

ABSTRACT:

Purpose of review

Psoriasis is a chronic inflammatory skin condition that is associated with increased cardiovascular risk compared to those without psoriasis. This review will cover emerging mechanisms of cardiovascular risk, key pathways targeted with biologic therapies, and the current evidence on therapies to modulate this risk in patients with psoriasis.

Recent findings

Recent scientific work has highlighted mechanisms that contribute to this enhanced risk, including the role of vascular endothelial dysfunction, platelet activation, dyslipidemia, and increased cardiometabolic comorbidities. Newer biologic and targeted synthetic therapies have transformed psoriasis treatment with high rates of clinical remission and durable skin disease control now possible. Epidemiologi

SUBMITTER: Weber B 

PROVIDER: S-EPMC9744099 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature