Ontology highlight
ABSTRACT:
SUBMITTER: He W
PROVIDER: S-EPMC9744384 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
He Wei W Henne Antonia A Lauterbach Mario M Geißmar Eike E Nikolka Fabian F Kho Celia C Heinz Alexander A Dostert Catherine C Grusdat Melanie M Cordes Thekla T Härm Janika J Goldmann Oliver O Ewen Anouk A Verschueren Charlène C Blay-Cadanet Julia J Geffers Robert R Garritsen Hendrikus H Kneiling Manfred M Holm Christian K CK Metallo Christian M CM Medina Eva E Abdullah Zeinab Z Latz Eicke E Brenner Dirk D Hiller Karsten K
Nature metabolism 20220501 5
Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity<sup>1-3</sup>. However, instead of investigating itaconate itself, most studies used derivatized forms of itaconate and thus the role of non-derivatized itaconate needs to be scrutinized. Mesaconate, a metabolite structurally very close to itaconate, has never been implicated in mammalian cells. Here we show that mesaconate is synthesized in inflammatory ...[more]