Embryonic lethality and defective mammary gland development of activator-function impaired conditional knock-in Erbb3 ^V943R mice.

ABSTRACT: ERBB3 is a pseudokinase domain-containing member of the ERBB family of receptor tyrosine kinases (RTKs). Following ligand binding, ERBB receptors homo- or hetero-dimerize, leading to a head-to-tail arrangement of the intracellular kinase domains, where the "receiver" kinase domain of one ERBB is activated by the "activator" domain of the other ERBB in the dimer. In ERBB3, a conserved valine at codon 943 (V943) in the kinase C-terminal domain has been shown to be important for its function as an "activator" kinase in vitro. Here we report a knock-in mouse model where we have modified the endogenous Erbb3 allele to allow for tissue-specific conditional expression of Erbb3 ^V943R (Erbb3 ^CKI-V943R ). Additionally, we generated an <

SUBMITTER: Senger K 

PROVIDER: S-EPMC9744554 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature