Autoencoder Networks Decipher the Association between Lung Cancer and Alzheimer's Disease.

ABSTRACT: Lung cancer is the most common malignancy and is responsible for the largest cancer-related mortality worldwide. Alzheimer's disease is a degenerative neurological disease that burdens healthcare worldwide. While the two diseases are distinct, several transcriptomic studies have demonstrated they are linked. However, no concordant conclusion on how they are associated has been drawn. Since these studies utilized conventional bioinformatics methods, such as the differentially expressed gene (DEG) analysis, it is naturally expected that the proportion of DEGs having either the same or inverse directions in lung cancer and Alzheimer's disease is substantial. This raises the inconsistency. Therefore, a novel bioinformatics method capable of determining the direction of association is desirable

SUBMITTER: Li J 

PROVIDER: S-EPMC9744611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature