Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.

ABSTRACT: Phospholipase Cε (PLCε) is a phospholipase C isoform with a wide range of physiological functions. It has been implicated in aortic valve disorders, but its role in frequently associated aortic disease remains unclear. To determine the role of PLCε in thoracic aortic aneurysm and dissection (TAAD) we used PLCε-deficient mice, which develop aortic valve insufficiency and exhibit aortic dilation of the ascending thoracic aorta and arch without histopathological evidence of injury. Fourteen days of infusion of Plce1^+/+ and Plce1^-/- mice with angiotensin II (ANG II), which induces aortic dilation and dissection, led to sudden death secondary to ascending aortic dissection in 43% of Plce1^-/- versus 5% of Plce1^+/+ mice (P

SUBMITTER: Atchison DK 

PROVIDER: S-EPMC9744656 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature