Identification of potential M2 macrophage-associated diagnostic biomarkers in coronary artery disease.

ABSTRACT:

Background

M2 macrophages have been reported to be important in the progression of coronary artery disease (CAD). Thus, the present study aims at exploring the diagnostic value of M2 macrophage-associated genes in CAD.

Methods

Transcriptome profile of CAD and control samples were downloaded from Gene Expression Omnibus database. The proportion of immune cells was analyzed using cell type identification by estimating relative subsets of RNA transcripts. Weighted Gene Co-expression Network Analysis (WGCNA) was carried out to screen the relevant module associated with M2 macrophages. Differential CAD and control samples of expressed genes (DEGs) were identified by the limma R package. Functional enrichment analysis by means of the clusterProfiler R package. Least absolute shrin

SUBMITTER: Li K 

PROVIDER: S-EPMC9744721 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature