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Exploring the "gene-protein-metabolite" network of coronary heart disease with phlegm and blood stasis syndrome by integrated multi-omics strategy.


ABSTRACT:

SUBMITTER: Yang G 

PROVIDER: S-EPMC9744761 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Exploring the "gene-protein-metabolite" network of coronary heart disease with phlegm and blood stasis syndrome by integrated multi-omics strategy.

Yang Guang G   Zhou Siyuan S   He Haoqiang H   Shen Zinuo Z   Liu Yongmei Y   Hu Jun J   Wang Jie J  

Frontiers in pharmacology 20221129


<b>Background:</b> According to the theory of traditional Chinese medicine, phlegm and blood stasis (PBS) is the pathological basis for coronary heart disease (CHD). This study aimed to explore the biological basis of PBS syndrome in CHD. <b>Methods:</b> Using a strategy that integrated RNA-seq, DIA-based proteomics, and untargeted metabolomics on 90 clinic samples, we constructed a "gene-protein-metabolite" network for CHD-PBS syndrome. We expanded the sample size and validated the differential  ...[more]

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